Abstract
Summary
1. Pretreatment doses of estrogens, which brought about marked curtailment in testicular androgen production as evidenced by sex accessory organ atrophy, increased the 3β-ol-dehydrogenase content of rat testicular homogenates. Estradiol- 17β was approximately 50 times more active than diethylstilbestrol dipalmitate in this respect. 2. This evidence suggests that the reaction catalyzed by the 3β-ol-dehydrogenase system is not the limiting one with respect to disrupted androgen production induced by estrogen pretreatment.
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