Abstract
Summary and conclusions
Concentrations of sulfamethoxypyridazine in blood and urine of 6 normal adult males were determined after a single oral dose of 4 g. The drug was well absorbed, yielding high levels of free drug and only small amounts in acetylated form in the plasma. Little if any of the drug diffuses into the blood cells. The drug is cleared slowly from the plasma, the acetylated form being cleared by the kidney about 11 times as fast as the free drug. Urine concentrations varied up to about 200 mg %, between 35 and 60% being in the conjugated form. Significant levels were still present in the blood and urine 105 hours after the dose. This prolonged action should be of clinical interest and suggests that further exploration of the potentialities of this new sulfonamide drug is warranted.
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