Abstract
Summary
(1) If sufficient phosphatide is intravenously administered to the rat to induce a continuous state of hyperphospholipi-demia, a state of hypercholesteremia also ensues. The hepatic concentration of cholesterol also is increased. (2) Phosphatide induced hypercholesteremia appears independent of sterol metabolism of liver as judged by assay of bile for cholesterol and cholate contents. Furthermore, total or partial hepa-tectomy increased the degree of hypercholesteremia induced by experimental hyperphos-pholipidemia. (3) Mobilization of extra-hepatic cholesterol and its subsequent deposition in the liver by experimental induction of hyperphospholipidemia appears to have possible therapeutic implications.
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