Abstract
Summary
Vit. K1 given intravenously in massive doses to dicumarol-treated rats and chicks did not influence the concentration of dicumarol in whole liver, the subcellular fractions (nuclei, mitochondria and supernatant) of liver, or whole blood, while the usual dicumarol-induced hypoprothrombinemia was prevented. The tissue distribution of dicumarol in the chick is like that in the rat.
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