Occurrence of Melanocyte Stimulating Hormone (MSH) in a Transplantable Pituitary Tumor

Abstract

Summary

Strain 2 adrenotropic tumors of LAF₁ mice were assayed for MSH, ACTH and vasopressin. The concentration of MSH was approximately that of the normal mouse pituitary. ACTH and vasopressin concentrations were very low. The possible relationship of MSH and ACTH was discussed. The adrenotropic tumor-bearing animal should be advantageous in the study of the action of MSH in the mammal.

The authors are indebted to Dr. Jacob Furth for supplying the tumor-bearing mice for transplantation and to Dr. Aaron B. Lerner for a standard preparation of MSH.