Anticortisol Action of 2-Methyl-9(α)-Fluorocortisol. ∗

Abstract

Summary

In adrenalectomized rats bearing a “granuloma pouch,” it has been demonstrated that 10 μg/day of 2-methyl-9(α)-fluoroeortisol (Me-F-COL) definitely antagonizes the catabolic, antiphlogistic, thymolytic and splenic atrophy-producing actions of 400 μg/day of Cortisol acetate (COLA). Higher doses of Me-F-COL are less effective in these respects. Since Me-F-COL possesses some glucocorticoid potency, in addition to its strong mineralocorticoid effect, the comparatively low anticortisol activity of this compound; when it is given at high dose-levels, is in agreement with expectations based on the “law of intersecting dose-effect curves.”