Abstract
Summary
The distribution of Be7 and of C14-labeled aurintricarboxylic acid (ATA) was studied autoradiographically over a period of 48 hours in the spleen, liver, lung and kidney of mice. It was found that in general beryllium and ATA were deposited in similar tissue loci. The highest simultaneous concentrations and identical patterns of deposition were seen in the red pulp of the spleen. Other organs showed reasonably good correlations in deposition of the two substances, confirming earlier therapeutic studies. An increased concentration of C14-ATA was observed in areas of tissue damage produced by beryllium in the liver, kidneys and lung.
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