Abstract
Summary and Conclusions
Abnormally shaped mast cells of peritoneal fluid in colchi-cine-treated rats are affected by the application of high hydrostatic pressure. The changes observed under pressure include rounding up of the cell, suggesting that the abnormal morphology is maintained by a strongly gelated cytoplasm. Induction of localized foci of gelation by colchicine is postulated to explain the formation of polymorphic mast elements.
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