Abstract
Summary
1. In fasted rats butyltolylsulfonylurea (BTSU) produces hypoglycemia and decreased liver glycogenolysis. 2. In rats fed glucose only, BTSU also produces hypoglycemia but the amount of liver glycogen is comparable to that of untreated glucose-fed rats. 3. After treatment of rabbits with BTSU for four days, the spontaneous glucose output from liver slices was less than from liver slices of control animals. 4. The formation of inorganic phosphate by liver homogenate in the presence of glucoses-phosphate is less in the BTSU-treated rats than in control rats, indicating that the glu-cose-6-phosphatase activity is less in the BTSU-treated rats than in control rats. 6. These observations tend to indicate that BTSU produces hypoglycemia at least partially by decreasing glucose-6-phosphatase activity in the liver.
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