Abstract
Summary
1) Fluorocitrate causes much less accumulation of citrate in the heart than does fluoroacetate. This is most likely due to relative impermeability of the heart to fluorocitrate. The same appears to apply to the brain. 2) C2 as well as C4 fragments of the Krebs cycle decrease the accumulation of citrate in the liver of fluorocitrate-poisoned animals. 3) Forty-eight hours' starvation reduces the citrate accumulation in the liver of fluorocitrate-poisoned rats to one-sixth the value obtained in fed animals.
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