Abstract
Summary
1. To be able to increase capillary resistance a steroid must possess the same chemical structural prerequisites as required for anti-inflammatory properties. 2. Alterations in cortisone molecule which potentiate its anti-inflammatory activity also increase capillary activity. 3. It seems that capillary activity, as measured by the capillary resistance test, is intimately related with the mechanism involved in the anti-inflammatory effect. 4. Capillary resistance test on adrenalectomized rat is proposed as a new bio-assay method for the demonstration of the anti-inflammatory activity of corticoids.
For compounds investigated we are indebted to the research departments of the following firms: Ciba Pharmaceutical Products, Merck and Co., Parke, Davis and Co., Sharp and Dohme, Schering Corp., and E. R. Squibb and Sons.
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