Abstract
Summary
Infection of mice with virus of Eastern equine encephalomyelitis induced an enhanced rate of phosphate transfer from blood to brain tissues, which could be markedly reduced by pretreatment of the infected animals with cortisone. Non-specific alteration of phosphate transfer to brain tissue could also be suppressed to a similar degree by cortisone treatment. Comparison of the E.E.E. virus growth in both cortisone-treated and untreated animals showed no effect of cortisone on rate of virus proliferation. The effect of this neurotropic virus infection on rate of phosphate transfer from blood to brain acid-soluble phosphates appeared to be due to inflammation, rather than to a specific metabolic requirement for virus synthesis.
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