Abstract
Summary
(1) A method to determine the in vitro steroid secretion by the rat adrenal is described. This procedure measures total steroid hormone production as well as secretion of steroids which have a 17, 21 dihy-droxy-20-ketone side chain. (2) It has been demonstrated that the in vitro secretion of adrenal hormones which possess a dihydroxy-ketone side chain amounts to almost one-half of the total steroid secretion. (3) The isolated rat adrenal secretes four steroid hormones in response to ACTH. The compound secreted in largest amount has been shown to be 11-epi-corticosterone.
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