Abstract
Summary
Post-extrasystolic potentiation (PEP) of cardiac contractility was studied in rabbit auricular muscle. It is shown that potentiation is related to the interval between basal beat and extrasystolic beat. An increase in driving rate up to about 3 per second increased the extent of potentiation and decreased the interval between basal beat and the extrasystole necessary for the production of maximal potentiation. Quinidine increased the effective refractory period and the interval for producing PEP and decreased the degree of potentiation produced by the extra-systole.
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