Abstract
Summary
Pancreatic extracts of cobalt-treated guinea pigs with a 4+ lesion fail to produce a significant hyperglycemia when assayed in cats; however, if well-granulated A cells remained in amounts roughly estimated above 25% of the normal, the extracts from these pancreases invariably elicited a hyperglycemia indistinguishable from that of the normal. These results are interpreted as strongly suggestive that glucagon originates from the A cells.
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