Abstract
Summary
Oxidative phosphorylation by rat brain homogenates was depressed by chlorpromazine at 2.5 × 10-4 M or greater, while reserpine at 25 and 50 μg/ml only slightly depressed oxygen uptake and phosphorylation. Effective concentrations of reserpine appeared to depress phosphorylation synergistically with chlorpromazine. Oxygen uptake was slightly increased with brain homogenates from animals treated with 10 mg/kg or chlorpromazine. Reserpine up to 50 mg/1 had no effect on enzymatic ATP breakdown, while chlorpromazine, at 1.2 × 10-4 M and 1.5 × 10-4 M depressed rat brain adenosinetriphosphatase slightly.
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