Abstract
Summary
The triglyceride concentration in livers of dogs maintained for 3 weeks on a high-fat, low-protein, choline-deficient diet was lowered by daily injections of heparin and by supplementation of the diet with choline. Oral administration of Aureomycin increased liver triglyceride concentrations. Choline, heparin or Aureomycin did not alter liver phosphatide or cholesterol concentrations of animals receiving the high-fat diet. Aureomycin, per os, did not affect in vitro synthesis of liver phosphatides, but modified the response of liver slices to the in vitro addition of choline.
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