Abstract
Summary
A peptidase, detectable by its action on chromogenic substrate glycyl-betanaphthylamine. is present in serum of most species. In guinea pig serum, hydrolysis of GBNA and protease inhibition show a marked parallelism: they have a similar kinetic behavior, they are inhibited by the same agents and are under the influence of the same hormones. Competitive inhibition of peptidase action by plasmin and trypsin suggest that proteases are substrates for peptidase and that antiproteolytic activity of guinea pig serum, is due? partly at least, to enzymatic destruction of proteases. In some other species this mechanism may be less important.
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