Abstract
Summary
In the experiments here given, serum from normal guinea pigs acted regularly and powerfully against cells of Lymphoma 6C3HED when these were implanted in mice of various breeds (C3H, AKR, A, DBA, and hybrid C3H x AKR). But it did not inhibit the cells of Lymphoma AKRL1 in hosts of the above mentioned sorts, and it likewise failed to inhibit growth of cells of 2 additional lymphomas (AKR13 and AKR17) in C3H mice. The findings make it plain that guinea pig serum does not act against the 3 types of AKR lymphoma cells even when these are implanted in alien hosts; indeed in some of the experiments guinea pig serum seemed to enhance the growth of AKRL1 cells in alien hosts. Considered together the observations weigh heavily against the supposition that the mouse host provides natural or induced isoantibodies which act in conjunction with guinea pig serum in killing the cells of I ymphoma 6C3HED in vivo, and they support the inference that cells of Lymphoma 6C3HED differ intrinsically from those of Lymphoma AKRL1, the former being susceptible to the effects of guinea pig serum in vivo while the latter are insusceptible.
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