Abstract
Summary
The time-course of respiratory C14O2 has been followed after intraperitoneal and intravenous dosage of NaHC14O3 into anesthetized and non-anesthetized rats. Nembutal has been shown to affect the turnover of injected bicarbonate through its depression of respiration. The anesthetic did not slow peritoneal absorption. The multiple bicarbonate dosage used did not lead to appreciable labeling in tissue lipids, and the contribution of C14O2 to secondary labeling reactions can under these conditions be ignored. Liver glycogen “fixed” a small but measurable amount of the C14 label.
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