Acceptance of Tumor Homografts by Mice Injected with Antiserum. I. Activity of Serum Fractions. ∗ †

Abstract

Summary

Antiserums to mouse tissues, produced in rabbits or mice, induce acceptance of an otherwise incompatible tumor homograft in mice, when injected into the host prior to grafting of the tumor. Activity of antiserums was associated with the globulin fractions, and was most concentrated in the gamma-globulin fraction. The activity was not impaired by treatment with sodium periodate, or by heating to 56°C. It was slightly impaired by heating to 70°C, and was destroyed at 100°C.