Systemic Effects of 2-isovaleryl-l,3-indandione

Abstract

Conclusions

1. 2-isovaleryl-1 3-indandi-one when given intravenously to cats in doses ranging from 5-60 mg/kg produces a decline in blood pressure which increases in severity with increase in dose. 2. Concomitant with the decline in blood pressure there is an increase in respiratory rate and depth. 3. These effects cannot be attributed to direct action on the heart, nor do they appear to be centrally mediated. 4. It is suggested that rapid vaso-dilation, with consequent drop in blood pressure, may produce a fatal vascular collapse.