Abstract
Summary
In a Swiss-Webster strain of mice, pertussis vaccine treatment increased the sensitivity to intravenously injected histamine 33 times, whereas surgical adrenalectomy had no significant effect on sensitivity to histamine. This finding, in addition to lack of direct evidence to the contrary, warrants the conclusion that Hemophilus pertussis vaccine enhances sensitivity of mice to histamine through some mechanism other than impairment of adrenal function.
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