Abstract
Summary
Observations on rats indicate that treatment with large doses of an ACTH-preparation, to which carboxymethylcellulose was added as a retarding agent, results in the development of mast-cell-like elements within the adrenal medulla. At the same time, in some cortical cells and in adrenal-vein blood, occasional granules appear, which give the characteristic staining reactions of mast-cell granules. Carboxymethylcellulose - solutions containing no ACTH produce similar changes.
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