Abstract
Summary
1. Ninety-three quinolines were tested against Streptococcus jaecalis in the presence of limiting amounts of folic acid. Ten of the quinolines were toxic to the organism when they were in the medium at concentrations of 8.0 to 200 νg/ml. The toxicity of 3 of the 10 inhibitors could be abolished. The inhibition of N-(2-diethylaminoethyl)-(7-chloro-3-methylquinolyl−4) - mercaptoacetamide was reversed by citrovorum factor, that of 7-chloro−4-(4-diethylaminobutylamino)-3-nitroquinoline was abolished by thymine, and that of N-2-diethylaminoethyl-6-methoxy-3-methylquinolyl − 4) - mercaptoacetamide was overcome by thymidine. The remaining 7 were not studied further since their degree of inhibition did not compare sufficiently favorably with that of some of the better known anti-folics. 2. None of 5 anti-malarials examined chloroquine, hydroxychloroquine, sontoquine, primaquine, and isopentaquine) interfered with the utilization of folic acid. Thus, these differ metabolically from pyrimethamine which has been shown to be both an anti-folic and an anti-malarial
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