Abstract
Summary
The present study is part of an investigation initiated in order further to purify and evaluate the goitrogenic substance (s) present in liver. The activity was found to be in the water insoluble portion of pork liver. Increased dietary iodine completely overcame its effect on thyroid size and iodine content. The decreased thyroid iodine of rats fed this material and inadequate iodine appears to be due to a fall in the protein bound fraction. This may be caused by an increased thyroxine secretion rate. Further experiments are in progress further to purify and study the metabolism of the active principle.
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