Abstract
Summary
Red cells from 3 patients with sickle cell-Hgb C disease transfused into normal individuals with and without a spleen, were found to have a survival time of approximately 50 days. The spleen, therefore, does not appear to have a critical role in the hemolysis occurring in this disease. Possible mechanisms for the red cell destruction, based on the per cent of Hgb S present, as well as the role of the spleen during periods of crisis, are discussed.
Get full access to this article
View all access options for this article.