Abstract
Summary
Salicylate, phenylbutazone, certain phenylbutazone derivatives and probenecid, all of which in high plasma drug concentrations increase the uric acid clearance, are demonstrated by appropriate renal clearance technics to depress the uric acid clearance at low plasma drug concentrations. The significance of this paradoxical reversibility of effects is discussed in relation to controversial aspects of phenylbutazone uricosuria, the phenomenon of “compensatory” uric acid retention after discontinuance of uricosuric agents, and the nature of tubular transport mechanisms for uric acid.
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