Abstract
Summary
1. Female rats were divided into groups and given chlorpromazine or anesthetic agents. One-half of each group was exposed to cold. The total non-protein sulfhydryl concentration (NPSH) of liver and kidney was determined and compared with similar values for control animals. Chlorpromazine and all anesthetics produced a decrease in liver NPSH. Cold further decreased the NPSH of animals anesthetized with phenobarbital, thiamylal, and thiopental; however, cold had no effect on liver NPSH of the chlorpromazine and pentobarbital groups. 2. Ether, nitrous oxide, and phenobarbital decreased kidney NPSH. No change was observed in the chlorpromazine and thiamylal groups, but a slight increase in kidney NPSH occurred in the thiopental group. The possible relationship of anesthetics on tissue NPSH and metabolism is discussed.
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