Abstract
Summary
A study of the effect of pepsin, carboxypeptidase, trypsin and chymotrypsin on the oxytocic activity of extracts of the rat hypothalamus and posterior lobe of the hypophysis. Both extracts show similar behavior. Chymotrypsin is the only enzyme that produces complete or almost complete loss of the oxytocic activity. No decrease in oxytocic activity is produced by the other enzymes. Incubation of the extracts at pH 7.3 without enzymes results in an appreciable loss of oxytocic activity by both extracts.
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