Abstract
Summary
The rate of disappearance of exogenous ACTH from the blood in the hypo-physectomized rat has been determined. Following subcutaneous injection of 10 U.S.P. ACTH units detectable blood ACTH activity was found within 1 minute. A peak concentration of 0.25 to 0.35 milliunit per ml blood took place 4 to 8 minutes after injection. No detectable activity was found after 80 minutes. Significant adrenal ascorbic acid depletion did not occur until about 28 minutes after the peak concentration of ACTH in the blood was reached.
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