Abstract
Summary
A simple and inexpensive method for producing antisera with a high degree of neutralizing capacity for poliomyelitis viruses has been described. By repeated intravenous injection of rabbits with small doses of poliomyelitis viruses grown in tissue culture, antisera with a high degree of homo-typic with little or no heterotypic neutralizing capacity have been produced regularly. Such antisera develop also to a lesser degree the capacity to lyse or agglutinate the cells in culture, in the absence of virus. When testing for heterotypic neutralization, this reaction may mask cross neutralization.
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