Abstract
Summary
Goldthioglucose injections, in the dose which produces obesity in mice, cause in these animals extensive hypothalamic damage involving the ventromedial nuclei. Such lesions are permanent in animals which in fact become obese, but are not apparent in animals unsuccessfully injected. Goldthiomalate, though as toxic as goldthioglucose, does not cause obesity; its injection does not lead to hypothalamic lesions. Implications of these findings as regards the mechanism of the regulation of food intake are discussed.
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