Inhibition of Lipid Synthesis by Alpha-Phenyl-N-Butyrate and Related Compounds

Abstract

Summary

1 Alpha-phenyl-n-butyrate at 1 × 10^-3 M has been shown to decrease rate of incorporation of acetate-1-C¹⁴ into cholesterol and into fatty acids by rat liver slices. 2) Incorporation of acetate into aceto-acetate is inhibited about the same extent, while oxidation to C0₂ is generally less strongly inhibited. 3) Endogenous oxygen consumption can proceed relatively unimpaired in the presence of 1 × 10^-3 M alpha-phenylbutyrate. 4) Several compounds structurally related to alpha-phenylbutyrate are also demonstrated to inhibit acetate incorporation into lipids. 5) The possible relation between present observations on inhibition of lipid synthesis and studies of Brodie et al.(14) on drug potentiators is discussed.