Cytotoxic Action of Influenza Virus. Failure to Induce Acquired Resistance Phenomenon in Tissue Culture. ∗

Abstract

Summary

Subtoxic virus, cholera filtrate and xerosin failed to protect HeLa cell cultures against the in vitro cytopathogenic effects of the Lee strain of influenza B virus and the WS and A/England/1/51 strains of influenza A virus. Smaller doses of these materials effectively rendered mice tolerant to the neurotoxic action of influenza viruses. The possible implications of these studies on the mechanisms by which the intact host acquires resistance to virus toxic action are discussed.