Abstract
Summary
The oestrogenic activity of 16 epi-oestriol was determined. Virgin, adult albino rats were ovariectomized, and 7 days later were put on experiments. A dose-response (0.01 to 100 μg) of this substance was determined utilizing the uterus and vagina as end points. The results from these experiments indicate that 1.0 μg of this oestrogen produces a slight effect on the vagina as well as on the uterus. Three daily doses of 40.0 μg of 16 epi-oestriol produced a maximal effect on the vagina (full cornincation) and the uterine weight. This substance seems to be the weakest of all the known naturally-occurring oestrogens described thus far.
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