Abstract
Summary
(1) Dilantin has a direct effect upon isolated rabbit gut. It reduces tone, reduces the amplitude and rate of contractions, and in higher concentrations can completely abolish the contractions. (2) The effect of Dilantin upon the isolated gut is rapidly reversible by simply replacing the gut in fresh Tyrode solution. (3) This effect of Dilantin is not due to its alkalinity. (4) Dilantin has a much more marked effect upon the gut than has sodium phenobarbital. (5) The clinical implications of these effects of Dilantin upon isolated gut are discussed briefly.
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