Abstract
Summary
It is believed that the salivary glands play no active role in metabolism of such thyroid analogues as DIT in the dog. The amount of iodide cleared into the saliva appears to be strictly a function of the circulating plasma level of iodide ion and is not influenced by exogenous thyroid hormone. This clearance will depend of course upon the rates with which exogenous diiodotyrosine. thyroxine and triiodothyronine become deiodinated. Since neither dog nor rat salivary glands appear to contain a DIT deiodinase system such as that found in liver and kidney tissue, it is concluded that these glands are not involved in the metabolism of DIT nor in the control of the circulating blood level of this analogue.
Get full access to this article
View all access options for this article.