Abstract
Summary
1. The livers of rat and of other animals, including man, contain an esterase, distinct from known cholinesterases, which hydrolyses succinylmonocholine. The enzyme is located in the mitochondria and can be extracted from a liver acetone-powder with dilute ammonium hydroxide. It has been partially purified by ammonium sulfate fractionation of a liver extract, and the final preparation was almost free of cholinesterase activity. The enzyme is TEPP insensitive. 2. The possible role of this enzyme in recovery of muscular control after succinyldicholine administration is discussed.
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