Abstract
Summary
1. Supernates of cultures of β-hemolytic streptococci were concentrated with respect to macromolecular material present. Such concentrates gave positive complement-fixation reactions with sera of rabbits which had been given courses of injections of living streptococci, and with sera of human subjects. 2. Evidence was obtained that complement-fixing antigenic material in such preparations was not identical with the complement-fixing fractions obtained from streptococcal cells, and complement fixation was probably not due to any of a number of the extracellular enzyme-antigens which can be found in streptococcal culture supernates.
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