Abstract
Summary
Simultaneous measurements of the renal clearance of PAS and creatinine in the dog indicate that the former substance is not excreted by the renal tubules. Benemid does not appear to diminish the renal clearance of PAS in the dog. This raises question as to the rationale of employing Benemid as an adjunct to PAS therapy in man. The volume of distribution of PAS appears to correspond closely with that of creatinine.
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