Effect of Coramine on Liver and Plasma Protein

Abstract

Summary

N, N-diethylnicotinamide (Cor-amine), when fed to weanling rats in a 25% protein diet, produced a marked increase in liver size within 3 to 6 days. This enlargement is due, in part, to an average absolute increase of up to 33% in liver protein. The optimal effect is obtained at a dietary level of about 0.5% Coramine. Plasma protein concentrations are slightly higher (5%) in experimental animals than in controls. Paper electrophoretic patterns of the proteins of these plasmas are identical with the patterns of control plasmas. These plasma and liver effects are obtained in a few days when the drug is fed at low dietary levels. Thus it would appear the Coramine acts as a liver growth stimulant in the young rat.