Abstract
Summary
1. Hyaluronidase or partially depolymerized hyaluronate enhanced the absorption of subcutaneously injected atropine so that this route was no different from the intravenous with regard to rapidity of onset. 2. Hyaluronidase or partially depolymerized hyaluronate also lowered the minimal effective dose of subcutaneous atropine necessary to antagonize pilocarpine induced salivation, 3. Hyaluronidase applied topically to the cornea shortened the induction time of a local anesthetic at the threshold concentration without affecting the duration of action. Higher concentrations of hyaluronidase abolished the local anesthesia.
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