Abstract
Summary and Conclusions
A factor sensitizing bacteria for phagocytosis is produced by dog blood cells. Sensitization results from direct contact of B. suis with dog but not guinea pig blood cells, or with a product of dog blood leucocytes diffusing into the suspension medium. The sensitizer differs from opsonin in that it is liberated from blood cells washed free of opsonin, from blood cells of animals free of specific opsonins, and is not fixed to sensitized bacteria. The sensitizer requires plasma but not opsonin for its action. It is not found in lysed washed dog or guinea pig blood cells, but is produced in demonstrable quantity by gentle agitation of dog leucocytes for 30 minutes at 37°C; it is not produced by dog red blood cells or guinea pig red or white blood ceils.
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