Abstract
Summary
1. Cholesterol supplements (4%, 2% and 1% in decreasing order of effect), increase the rate of occurrence of cardiovascular lesions in choline-deficient female and male rats which are resistant to the effects of choline-deficiency alone. 2. The significance of kidney damage in the production of these cardiovascular lesions is discussed. 3. The aggravating effect of cholesterol on choline-deficient tissues occurs in the presence of decreased serum cholesterol levels. 4. The significance of choline in the production of experimental arteriosclerosis depends upon the procedures used. Under certain circumstances the presence of choline in the diet is apparently necessary for the production of (atheroma-like) lesions. In others choline deficiency results in or favors the production of cardiovascular lesions (Moenckeberg type). The nature and the mechanism of production of the two types of cardiovascular lesions are quite different.
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