Abstract
Summary
(1) Among typical human type tubercle bacilli and their isoniazid-resistant mutants, there is a relationship between degree of isoniazid resistance and the magnitude of endogenous catalase activity; as the level of resistance to isoniazid increases, the endogenous catalase activity decreases. (2) At a given level of isoniazid resistance, there is a decrease in pathogenicity for the guinea pig which, in general, is directly related to a decrease in catalase activity.
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