Abstract
Summary
A more complete destruction of virus occurred at acid reactions (pH 6.2) as opposed to alkaline reactions. The results with 5 × 10−3 M mustard also indicated that at alkaline reactions destruction of viral infectivity was completed during the first half minute of mustard-virus interaction. In contrast, at pH 6.2 the action of mustard upon virus extended beyond this half minute and led to complete inactivation of virus which survived the initial period of reaction. 2. A comparison of the interfering capacity of virus inactivated with 5 × 10−3 M mustard at pH 8.0 with that of virus treated with 5 × 10−4 M mustard at pH 6.2 revealed a marked interfering effect for the latter. This observation would appear to suggest a convenient procedure for preparation of interfering suspensions of virus for studies of the interference phenomenon.
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