Glucocorticoid and Mineralocorticoid Activities of Δ 1 -Fluorohydrocortisonei

Abstract

Summary

(1) Comparisons have been made of relative potencies of hydrocortisone, fluorohydrocortisone, Δ¹-hydrocortisone, and Δ¹-fluorohydrocortisone in causing deposition of liver glycogen and reduction of sodium excretion in the adrenalectomized rat. (2) In glycogen deposition potency, the compounds have activity of the following magnitude: Δ¹-fluorohydrocortisone acetate-50; fluorohy-drocortisone acetate-12.6; Δ¹-hydrocorti-sone-2.9; hydrocortisone-1. (3) In sodium-retaining potency, the compounds have activity of the following magnitude: Δ¹-fluorohydrocortisone acetate-4.6; fluorohydro-cortisone acetate-5.0; Δ¹-hydrocortisone acetate-very slight; hydrocortisone acetate -very slight; DOCA-1.