Abstract
Summary
1. The greatly increased blood levels of phenylalanine that occur in phenylketonuria do not cause a significant quantitative alteration from normal of the serum protein pattern. 2. Occasional serums of children with phenylketonuria contain abnormal β-globulins. These abnormalities disappear when they are fed phenylalanine-low diets and the blood phenylalanine is lowered to the normal range. There appears to be no correlation between the presence of the abnormal β-globulins and the degree of mental impairment. 3. It is suggested that the abnormal globulins are manifestations of slight liver dysfunction.
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