Abstract
Summary
The purine and pyrimidine composition of brain cytoplasmic pentose nucleic acid from normal mice and mice infected with the MEF1 strain of poliomyelitis virus was investigated. For this purpose, two different methods of hydrolysis and chromatography were applied to isolated and purified PNA preparations, and the results were found to be in good agreement. A small but apparently significant rise in uracil content in pentose nucleic acid was observed in the brains of mice showing paralytic symptoms of central nervous system involvement.
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